What are you on right now?

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Re: What are you on right now?

Unread postby poolerboy0077 » 17 May 2019, 12:36

René wrote:
Eryx wrote:I just had a surgery (deviated septum) so I'm on strong painkillers, antibiotic, and anti-inflammatory. I somehow feel like there may be even a little high going on.

Don't get addicted!

In your druggie opinion, how does this happen?
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Re: What are you on right now?

Unread postby erti » 9 August 2019, 23:40

Hmm... I wanna try psychedelics drugs just to see if a drug induced psychosis is like my schizophrenic psychosis. Not that I'm actively looking for them and I have no plan on doing so because I'm not stable on my meds yet. I hear shrooms are the safest as far as psychedelics goes. I know "drugs are bad mkay"... I'm just glad weed doesn't make me paranoid and actually helps a little with the voices... however not so much with the visuals. eh oh well. Just random thoughts. don't take me seriously. I know drugs are bad. lol
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Re: What are you on right now?

Unread postby erti » 10 August 2019, 01:50

Well a according to my druggy friend it doesn’t cause psychosis unless taken a lot of it. So hmph
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Re: What are you on right now?

Unread postby René » 10 August 2019, 08:47

erti wrote:Well a according to my druggy friend it doesn’t cause psychosis unless taken a lot of it. So hmph

In someone without a psychotic disorder, that is generally the case. But everyone has a different threshold for psychotic symptoms to be triggered. One person might take, e.g., 150 µg of LSD and get some visual effects but no serious disturbance of normal thought. Another person might enter a full-blown psychotic episode from taking 50 µg or less. It can also vary from time to time.

Mushrooms are difficult to dose reliably because the concentration of psilocin and psilocybin can vary a lot. They're also not very gentle on the stomach (though some people have no issues).

I've had much more luck with certain analogues of LSD, like 1p-LSD. These have the added benefit of not being unambiguously illegal in most places (especially if technically not intended for human consumption), which means you don't need to rely on criminal drug dealers to get them and, if you use a reputable vendor, you can actually be sure it contains what it's supposed to in the dosage you were expecting.

Note that antipsychotics tend to work partly by blocking the main receptor psychedelics work through (the 5-HT2A receptor) and so reduce their effects.

Anyway, I think you'd want to think this through very carefully as it seems like a highly dangerous experiment just to satisfy a curiosity.
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Re: What are you on right now?

Unread postby René » 10 August 2019, 09:04

poolerboy0077 wrote:
René wrote:
Eryx wrote:I just had a surgery (deviated septum) so I'm on strong painkillers, antibiotic, and anti-inflammatory. I somehow feel like there may be even a little high going on.

Don't get addicted!

In your druggie opinion, how does this happen?

This will be heavily simplified of course, and I'm assuming the strong painkillers are opioids and not just high-dose ibuprofen or something.

It's negative feedback, homeostasis and hijacking of the brain's reward system.

Your body "expects" a certain amount of µ-opioid neurotransmission to be going on at any given time. If there's a sustained excess, it reacts in ways that will tend to reduce it, chiefly by downregulating (reducing the expression/density of) the µ-opioid receptor and inhibiting release of the endogenous substances that activate it, like β-endorphin. If there's a sustained drop, it'll do the reverse.

Activation of this receptor also has downstream effects that result e.g. in increased dopamine neurotransmission in parts of your brain associated with pleasure — there, the dopamine receptors will be downregulated.

All this results in tolerance, meaning you need more and more to achieve the same effect, and dependence, meaning you'll actually (temporarily or permanently) have less of all this neurotransmission going on if you stop than if you'd never started.

Anyway, those downstream effects trigger responses you're supposed to get to things that make evolutionary sense, like eating good food and having sex, and they are "supposed" to be controlled by other regulatory mechanisms. Uncontrolled, unregulated activation of all the µ-opioid receptors you've got throws the whole system out of whack. Your brain is a pattern-detection machine, and it quickly learns to associate taking these pills with those responses. Essentially, taking the drug becomes exactly the same kind of drive as the drive to eat.

If you take only the amount you need to be comfortable, the amount you need should drop as you heal. But that's a best-case scenario — it may not drop. I imagine what happens when people get addicted to prescribed painkillers is that the dosage isn't dropped as it needs to be to avoid addiction but is kept the same or increased because pain relief is felt to be insufficient. The problem is that the more you take, the more you need to keep getting the same response that you're used to, and the longer you take it, the longer it takes to return to a normal state and the more unpleasant that is going to be.
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Re: What are you on right now?

Unread postby erti » 10 August 2019, 09:40

René wrote:
erti wrote:Well a according to my druggy friend it doesn’t cause psychosis unless taken a lot of it. So hmph

In someone without a psychotic disorder, that is generally the case. But everyone has a different threshold for psychotic symptoms to be triggered. One person might take, e.g., 150 µg of LSD and get some visual effects but no serious disturbance of normal thought. Another person might enter a full-blown psychotic episode from taking 50 µg or less. It can also vary from time to time.

Mushrooms are difficult to dose reliably because the concentration of psilocin and psilocybin can vary a lot. They're also not very gentle on the stomach (though some people have no issues).

I've had much more luck with certain analogues of LSD, like 1p-LSD. These have the added benefit of not being unambiguously illegal in most places (especially if technically not intended for human consumption), which means you don't need to rely on criminal drug dealers to get them and, if you use a reputable vendor, you can actually be sure it contains what it's supposed to in the dosage you were expecting.

Note that antipsychotics tend to work partly by blocking the main receptor psychedelics work through (the 5-HT2A receptor) and so reduce their effects.

Anyway, I think you'd want to think this through very carefully as it seems like a highly dangerous experiment just to satisfy a curiosity.


Makes sense. I'm curious but not THAT curious. I guess psychosis is psychosis and it effects people different ways. I know when I go to sleep I sometimes hear my name being called and country music and it's a totally different than my usual psychotic state. It's no where near what I normally see and hear and think. But I know hallucinations before falling asleep and before waking up is pretty normal. I forgot what it's called. but from what I heard it's normal. I also don't want to go into a bad trip and not come out of it. My hallucinations are already pretty bad but I take antipsychotics so as you said will reduce the effect. Plus it would be a bad idea if I ended up stable and off meds to take the drug because I don't want to trigger another psychotic episode and have to get back on medication again but to be quite frank... I don't think I'll ever get off meds.
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Re: What are you on right now?

Unread postby Yeauxleaux » 11 August 2019, 20:26

I wish I was on my co-worker's face tbh.

I'm developing something of a crush and (I'm assuming anyway, I actually don't know but whatever) he's straight so it's not for the best. He has the nicest neatly-groomed beard though I just wanna play with it so badly.
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Re: What are you on right now?

Unread postby Marmaduke » 11 August 2019, 20:38

Yeauxleaux wrote:I wish I was on my co-worker's face tbh.

I'm developing something of a crush and (I'm assuming anyway, I actually don't know but whatever) he's straight so it's not for the best. He has the nicest neatly-groomed beard though I just wanna play with it so badly.

This is the guy you’ve spoken about before, right? Want me to come wing-man this situation for you? You can be tickling your taint with his beard in no time.
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Re: What are you on right now?

Unread postby Yeauxleaux » 11 August 2019, 20:40

Marmaduke wrote:
Yeauxleaux wrote:I wish I was on my co-worker's face tbh.

I'm developing something of a crush and (I'm assuming anyway, I actually don't know but whatever) he's straight so it's not for the best. He has the nicest neatly-groomed beard though I just wanna play with it so badly.

This is the guy you’ve spoken about before, right? I can totally wing-man this situation for you.
No this is another one haha, the one before who looked like Scar from The Lion King was definitely straight and he left in May.

This one I'm like 99% sure he's straight but he's just so handsome and has such big dick energy it's so magnetic.

And well if you're sure of your skills haha ;)
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Re: What are you on right now?

Unread postby mxguy01 » 12 August 2019, 17:01

Straight guys wont stand a chance with you two on the prowl. LoL.
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Re: What are you on right now?

Unread postby Marmaduke » 12 August 2019, 17:28

mxguy01 wrote:Straight guys wont stand a chance with you two on the prowl. LoL.

I’m quite the suave operator, I’ll have you know. :cool:
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