What made your day / made you smile today?

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Re: What made your day / made you smile today?

Unread postby Severelius » 23 November 2020, 13:32

Just found there's a cast recording of the Mary Poppins stage production on Spotify that was recorded with the same main cast that were performing when I went to watch the show in person. And it's just delightful to relive it.

God I miss going to the theatre...
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Re: What made your day / made you smile today?

Unread postby Brenden » 23 November 2020, 17:17

Magic J wrote:https://www.research.ox.ac.uk/Article/2 ... 19-vaccine

Oxford vaccine trials have announced that their chAdOx1 vaccine appears to be 70% effective, 90% effiacy with dosage modification, and much more easily stored and transported than Pfizer/Moderna vaccines. More trials ongoing, hoping to replicate results. Excellent work from Oxford. A good candidate for international distribution.

70% doesn't seem anywhere near good enough. What we really need is a vaccine that is ≥90% effective with just standard doses that is easy to manufacture, store, and distribute. Getting people to get just 1 vaccination is difficult enough; it's going to be very difficult to make sure people get their second doses when they're supposed to.
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Re: What made your day / made you smile today?

Unread postby Magic J » 23 November 2020, 17:51

Brenden wrote:70% doesn't seem anywhere near good enough. What we really need is a vaccine that is ≥90% effective with just standard doses that is easy to manufacture, store, and distribute. Getting people to get just 1 vaccination is difficult enough; it's going to be very difficult to make sure people get their second doses when they're supposed to.

Their press release indicates that the 70% figure is an average between two sub-trials which used different dosing regimes ("high dose + high dose and low dose + high dose), with low dose + high dose approaching 90% effiacy in the initial results.

I'm pretty sure if somebody commits to a first dose they'll follow up with the second but maybe I'm wrong on that. I assume there will be enough uptake here to bring down transmission rates significantly, but the conspiracy mill has been working overtime, so I dunno to be honest. I don't personally know anyone who'd refuse it, at any rate, though that's not exactly a good indicator. :P
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Re: What made your day / made you smile today?

Unread postby Brenden » 23 November 2020, 18:00

There are so many people who don't even finish their full course of antibiotics because they start feeling better, I really worry that a lot of people may take the first dose and then think that they're protected enough to not bother with the second.

Never underestimate the abject stupidity of the general populace.
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Re: What made your day / made you smile today?

Unread postby René » 24 November 2020, 00:15

Magic J wrote:
Brenden wrote:70% doesn't seem anywhere near good enough. What we really need is a vaccine that is ≥90% effective with just standard doses that is easy to manufacture, store, and distribute. Getting people to get just 1 vaccination is difficult enough; it's going to be very difficult to make sure people get their second doses when they're supposed to.

Their press release indicates that the 70% figure is an average between two sub-trials which used different dosing regimes ("high dose + high dose and low dose + high dose), with low dose + high dose approaching 90% effiacy in the initial results.

I'm pretty sure if somebody commits to a first dose they'll follow up with the second but maybe I'm wrong on that. I assume there will be enough uptake here to bring down transmission rates significantly, but the conspiracy mill has been working overtime, so I dunno to be honest. I don't personally know anyone who'd refuse it, at any rate, though that's not exactly a good indicator. :P
Brenden wrote:There are so many people who don't even finish their full course of antibiotics because they start feeling better, I really worry that a lot of people may take the first dose and then think that they're protected enough to not bother with the second.

Never underestimate the abject stupidity of the general populace.

The vaccines can also cause side effects which may cause people to not want to get the second dose. These can be similar to symptoms associated with mild Covid-19, such as muscle pain, chills and headaches.

Doctors say CDC should warn people the side effects from Covid vaccine shots won’t be ‘a walk in the park’
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Re: What made your day / made you smile today?

Unread postby erti » 24 November 2020, 00:27

I cleaned out my friends car.. I found my boots while cleaning :D... cleaned them up and good as new.
“Don't take my devils away, because my angels may flee too.”

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Re: What made your day / made you smile today?

Unread postby Magic J » 24 November 2020, 07:45

René wrote:The vaccines can also cause side effects which may cause people to not want to get the second dose.

Yeah, estimated 20% experiencing a "febrile reaction", apparently. I was pleased to see that Dr. Phil Whitaker (writing for New Statesman) recommended being upfront about this. Refusing to acknowledge possible (usually mild} reactions leaves a lot of space of conspiracy to foment...
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Re: What made your day / made you smile today?

Unread postby Marmaduke » 24 November 2020, 09:25

No, no, you’re right. This Oxford vaccine is as good as water. We should throw it in the bin, tell everyone involved that they should be ashamed of their own incompetence, and just continue living in a mismanaged state of nationwide lockdown whilst a new team from Cambridge is instructed “think of this as the boat race that those incompetent Oxford pricks failed to make viable, show them who’s best”
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Re: What made your day / made you smile today?

Unread postby Magic J » 24 November 2020, 10:10

I'm told that it's borderline miraculous to get vaccines this effective developed in such a short space of time. Immunoligists were hoping for 50% effiacy not too long ago, so the Pfizer and Oxford vaccines surpass all expectations. They deserve prizes.

Not too sure about Sputnik, though. Have the trial results been verified yet?
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Re: What made your day / made you smile today?

Unread postby PopTart » 24 November 2020, 10:16

Magic J wrote:I'm told that it's borderline miraculous to get vaccines this effective developed in such a short space of time. Immunoligists were hoping for 50% effiacy not too long ago, so the Pfizer and Oxford vaccines surpass all expectations. They deserve prizes.

Not too sure about Sputnik, though. Have the trial results been verified yet?

It does make you wonder what could be done with other diseases though. Funny how the world can come up with 3 seperate, pretty effective vaccines in a hurry, when doing so protects financial interests and likely makes a boat load of cash too.
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Re: What made your day / made you smile today?

Unread postby John27 » 24 November 2020, 10:23

Magic J wrote:I'm told that it's borderline miraculous to get vaccines this effective developed in such a short space of time.


I can't see why a fast vaccine isn't possible. After all, I keep hearing those who say that COVID is a fake virus. So it shouldn't take much time at all to create a fake vaccine. The tough part is probably shrinking down the microchips that will be included to track people.

:lol:
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Re: What made your day / made you smile today?

Unread postby Magic J » 24 November 2020, 10:30

PopTart wrote:... likely makes a boat load of cash too.


Not entirely clued up on the details, but I believe that Oxford and their production/distribution partner have said they'll initially sell their vaccine on a not for profit basis (a very low price, I assume) to governments that can least afford it. In which case I'd say they deserve a prize in lieu of market profit.
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Re: What made your day / made you smile today?

Unread postby Marmaduke » 24 November 2020, 10:37

John27 wrote:
Magic J wrote:I'm told that it's borderline miraculous to get vaccines this effective developed in such a short space of time.


I can't see why a fast vaccine isn't possible. After all, I keep hearing those who say that COVID is a fake virus. So it shouldn't take much time at all to create a fake vaccine. The tough part is probably shrinking down the microchips that will be included to track people.

:lol:

The Pfizer vaccine, whilst effective, would not be viable outside of a state of global emergency. It needs to be stored and transported at -70 Celsius. As soon as it drops below that, it can’t be refrozen. It has to be used within hours. It cannot be rolled out anywhere in the world without a significant military logistics operation and doses also require the purchase of specialised and very expensive refrigerated cases. The planes and trucks used to transport it can’t carry nearly as much as they could of another vaccine because of the weight of refrigerators and refrigerant that comes with them.

In any other circumstance than desperation, Pfizer wouldn’t even try and sell this because nobody would buy it.
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Re: What made your day / made you smile today?

Unread postby John27 » 24 November 2020, 10:43

PopTart wrote:It does make you wonder what could be done with other diseases though. Funny how the world can come up with 3 seperate, pretty effective vaccines in a hurry, when doing so protects financial interests and likely makes a boat load of cash too.


Yes. One does wonder..

It's amazing and saddening in one way--we've had HIV longer than some on this forum have even been alive. And finding anything for HIV/AIDS took forever as I recall. And we still don't have a vaccine (although I've heard there are issues that may make a HIV vaccine hard or impossible). For years, the best they could say was "use a condom." And yet, in about a year, they've come up with a vaccine for COVID. Protecting the economy, so the rich get richer, is more important than gay people, I guess. :cry:

(Although I guess I'm a bit bitter with HIV, since I lived through the 80s, when AIDS was scary news every day for a period. That fear of AIDS had a profoundly negative impact on me.)

Although I think I had also heard that there was some research and development going on. Obviously, not for COVID specifically, since it was unknown. But in areas similar enough that they could use existing research for COVID. Although I don't know that any of the current vaccine candidates have used any of this research.
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Re: What made your day / made you smile today?

Unread postby PopTart » 24 November 2020, 11:37

Magic J wrote:
PopTart wrote:... likely makes a boat load of cash too.


Not entirely clued up on the details, but I believe that Oxford and their production/distribution partner have said they'll initially sell their vaccine on a not for profit basis (a very low price, I assume) to governments that can least afford it. In which case I'd say they deserve a prize in lieu of market profit.

Let's wait and see if they are good to their word before we start handing out the awards.

And which countries actually qualify for this special discount rate. How short will this short list be?

Marmaduke wrote:
John27 wrote:
Magic J wrote:I'm told that it's borderline miraculous to get vaccines this effective developed in such a short space of time.


I can't see why a fast vaccine isn't possible. After all, I keep hearing those who say that COVID is a fake virus. So it shouldn't take much time at all to create a fake vaccine. The tough part is probably shrinking down the microchips that will be included to track people.

:lol:

The Pfizer vaccine, whilst effective, would not be viable outside of a state of global emergency. It needs to be stored and transported at -70 Celsius. As soon as it drops below that, it can’t be refrozen. It has to be used within hours. It cannot be rolled out anywhere in the world without a significant military logistics operation and doses also require the purchase of specialised and very expensive refrigerated cases. The planes and trucks used to transport it can’t carry nearly as much as they could of another vaccine because of the weight of refrigerators and refrigerant that comes with them.

In any other circumstance than desperation, Pfizer wouldn’t even try and sell this because nobody would buy it.

Yikes! :noes:

Thats a success? :squint:

John27 wrote:
PopTart wrote:It does make you wonder what could be done with other diseases though. Funny how the world can come up with 3 seperate, pretty effective vaccines in a hurry, when doing so protects financial interests and likely makes a boat load of cash too.


Yes. One does wonder..

It's amazing and saddening in one way--we've had HIV longer than some on this forum have even been alive. And finding anything for HIV/AIDS took forever as I recall. And we still don't have a vaccine (although I've heard there are issues that may make a HIV vaccine hard or impossible). For years, the best they could say was "use a condom." And yet, in about a year, they've come up with a vaccine for COVID. Protecting the economy, so the rich get richer, is more important than gay people, I guess. :cry:

(Although I guess I'm a bit bitter with HIV, since I lived through the 80s, when AIDS was scary news every day for a period. That fear of AIDS had a profoundly negative impact on me.)

Although I think I had also heard that there was some research and development going on. Obviously, not for COVID specifically, since it was unknown. But in areas similar enough that they could use existing research for COVID. Although I don't know that any of the current vaccine candidates have used any of this research.
you kidding?! HIV/AIDS is a cash cow. They aren't "curing" that. Between the wealthy of the west and the multitudes of infected in Africa, they have a market for life.

I don't think it's a surprise that the only disease we have effectively wiped out is smallpox :lol:

Treatments net more more cash than cures.

If that wasn't the priority, we would see more efforts to combat rare diseases, with fewer sufferers.
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Re: What made your day / made you smile today?

Unread postby John27 » 24 November 2020, 11:48

PopTart wrote:Treatments net more more cash than cures.


No kidding! And trust me: that's a thought I've often had, as I ponder healthcare--particularly here in the US.
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Re: What made your day / made you smile today?

Unread postby PopTart » 24 November 2020, 13:21

John27 wrote:
PopTart wrote:Treatments net more more cash than cures.


No kidding! And trust me: that's a thought I've often had, as I ponder healthcare--particularly here in the US.

Whats even worse is that, big pharma in the US, use public funds to develop medicine and treatments, then get patents for them and sell them to the public at exorbitant markups. :facepalm2:
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Re: What made your day / made you smile today?

Unread postby Magic J » 24 November 2020, 13:22

PopTart wrote:Let's wait and see if they are good to their word before we start handing out the awards.

And which countries actually qualify for this special discount rate. How short will this short list be?

Well yes, that's why I cared to prefix it with "In which case". :P

I don't know which countries will "qualify", the details of distribution are still being worked out. Do allow me at least a small measure of optimism that this could be a good development.

Although, I do read that AstraZeneca (Oxford partner) seem to have been given licence to declare the pandemic over (at which point they could stand to profit hugely with repeat vaccinations). That does seem very troublesome... I'll be back to my usual cynicism in no time!
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Re: What made your day / made you smile today?

Unread postby erti » 24 November 2020, 20:17

nothing really happen to make me smile or made my day but I got up, took morning meds, took a shower, change clothes, wash dishes, cleaning. and take my 2pm meds, I actually feel good today.
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Re: What made your day / made you smile today?

Unread postby Severelius » 26 November 2020, 19:15

Normal entry: I finally de-cluttered my bedroom and the living room of all the rubbish and crap that had been building up for most of Lockdown 2 and that was driving me insane so my living space just feels much more liveable now, which is nice.

Nerdy entry: After an understandable long gap in production, the BBC finally announced the next of their Blu-ray box set remasters of classic Doctor Who seasons, and it's a season I really love like every story in so hoorah.
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